Inhibition by oxalomalate of rat liver mitochondrial and extramitochondrial aconitate hydratase
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چکیده
منابع مشابه
The inhibition by fluorocitrate of rat liver mitochondrial and extramitochondrial aconitate hydratase.
1. The effects of synthetic fluorocitrate were studied on: (a) the oxidation of citrate and cis-aconitate by rat liver mitochondria; (b) the activity of the aconitate hydratase found in the liver cell sap; (c) the activity of the aconitate hydratase solubilized from liver mitochondria. 2. Fluorocitrate was found to be a potent inhibitor of oxidation of citrate but only a weak inhibitor of oxida...
متن کاملFluorocitrate inhibition of aconitate hydratase and the tricarboxylate carrier of rat liver mitochondria.
1. The effect of biologically synthesized and purified fluorocitrate on the metabolism of tricarboxylate anions by isolated rat liver mitochondria was investigated, in relation to the claim by Eanes et al. (1972) that this fluoro compound inhibits the tricarboxylate carrier at concentrations at which it has little effect on the aconitate hydratase activity. 2. That the inhibitory action of fluo...
متن کاملThe inhibition of plant aconitate hydratase (aconitase) by fluorocitrate.
Fluoroacetate is a potent poison of animals. It is metabolized to fluorocitrate, which is a powerful inhibitor of mammalian aconitate hydratase [aconitase; citrate (isocitrate) hydrolyase] (Peters, 1952). Fluoroacetate and fluoroacetamide, as systemic insecticides for plants, are taken up by the roots or absorbed by the leaves and are then translocated to other parts of the plant. The plants sh...
متن کاملInhibition of Mitochondrial Aconitase by Succination in Fumarate Hydratase Deficiency
The gene encoding the Krebs cycle enzyme fumarate hydratase (FH) is mutated in hereditary leiomyomatosis and renal cell cancer (HLRCC). Loss of FH activity causes accumulation of intracellular fumarate, which can directly modify cysteine residues to form 2-succinocysteine through succination. We undertook a proteomic-based screen in cells and renal cysts from Fh1 (murine FH)-deficient mice and ...
متن کاملInhibition of aconitase by trans-aconitate.
Bernheim (2), studying the properties of the “citric dehydrogenase” system, noted that aconitic acid (presumably the trans isomer) inhibited the reduction of methylene blue by citric acid. More recently, Morrison and Still (3), in a short report, claimed that truns-aconitic acid inhibited competitively the reaction cis-aconitate c citrate, catalyzed by the aconitase of rhubarb leaf. The present...
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ژورنال
عنوان ژورنال: Biochemical Journal
سال: 1971
ISSN: 0306-3283
DOI: 10.1042/bj1250557